Advances in endometriosis management, diagnosis, treatment, and impacts on fertility: A literature review

Authors

DOI:

https://doi.org/10.62827/fb.v26i5.1103

Keywords:

Endometriosis; Fertility; Disease Management; Diagnostic Techniques; Physical Therapy.

Abstract

Introduction: Endometriosis is a chronic gynecological disease that affects women's fertility, quality of life, and well-being, requiring early diagnosis and individualized management strategies. In addition to the medical approach, physical therapy plays a complementary role in pain reduction and functional rehabilitation. Objective: A literature review was conducted on advances in the diagnosis, treatment, and impact of endometriosis on fertility, emphasizing surgical approaches, hormonal therapies, clinical follow-up, and rehabilitation strategies. Methods: A descriptive and analytical literature review was conducted based on national and international publications available in the Virtual Health Library (VHL), Scientific Electronic Library Online (SciELO), and PubMed databases. Studies published between 2013 and 2023 in Portuguese and English were included, covering reviews, clinical studies, narrative studies, and observational studies. Interviews, isolated opinion reports, and duplicate materials were excluded. The selection took place in three stages: identification, screening of titles and abstracts, and full reading of eligible texts. Results: The literature shows that integrated strategies, combining early diagnosis, minimally invasive surgical interventions, individualized hormone therapies, continuous clinical follow-up, and physiotherapeutic support, promote pain reduction, fertility preservation, and improved quality of life. Advanced technologies, such as robotic surgery and intrauterine hormonal devices, have demonstrated a positive impact on clinical and reproductive outcomes. The main barriers include delayed diagnosis, unequal access to specialized procedures, and partial adherence to therapies. Conclusion: Effective management of endometriosis requires a multidisciplinary and individualized approach, integrating medicine and physical therapy, clinical protocols, modern technologies, and continuous monitoring. Investments in professional training, health education, and structuring of care flows are essential to optimize clinical and reproductive outcomes.

Author Biographies

  • Thaís Cançado Leite, PUC-MG

    Formada pela Pontifícia Universidade Católica de Minas Gerais (PUC-MG), Belo Horizonte, MG, Brasil

  • Lucas Oliveira e Souza, FCM-MG

    Formado pela Faculdade de Ciências Médicas de Minas Gerais (FCM-MG), Belo Horizonte, MG, Brasil

  • Letícia Pereira Mendonça, FAMINAS

    Formada pelo Centro Universitário FAMINAS, Belo Horizonte, MG, Brasil

  • Raphael Pereira Mendonça, FAMINAS

    Acadêmico do Centro Universitário FAMINAS, Belo Horizonte, MG, Brasil

References

Cruz BA, Pereira TM, Santos LM, et al. Endometriose e seu impacto na infertilidade feminina. Res Soc Dev [Internet]. 2022 Sep [cited 2025 Oct 9];11(9):e60011932371-e60011932371. Available from: https://bjihs.emnuvens.com.br/bjihs/article/view/1716

De Mendonça MFM, Lima AC, Oliveira R, et al. Endometriose: manifestações clínicas e diagnóstico–revisão bibliográfica. Braz J Health Rev [Internet]. 2021 Jan [cited 2025 Oct 9];4(1):3584-3592. Available from: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/25214

Duarte AN, Righi M. Associação entre endometriose e infertilidade feminina: uma revisão de literatura. Acta Elit Salutis [Internet]. 2021 [cited 2025 Oct 9];4(1). Available from: https://e-revista.unioeste.br/index.php/salutis/article/view/26895

Gama AV, Almeida LM, Souza JC, et al. A endometriose e sua abordagem cirúrgica. Braz J Dev [Internet]. 2023 [cited 2025 Oct 9];9(6):19151-19161. Available from: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/60446

Lopes AB, Costa FN, Silva EP, et al. Abordagem sobre a endometriose: revisão narrativa. Rev Eletr Acervo Cient [Internet]. 2022 [cited 2025 Oct 9];42:e11022-e11022. Available from: https://acervomais.com.br/index.php/cientifico/article/view/11022

Moretto EE, Oliveira TS, Lima RM, et al. Endometriose. Promoção e proteção da saúde da mulher, ATM 2023/2. Rev UFRGS [Internet]. 2021 [cited 2025 Oct 9];53-64. Available from: https://lume.ufrgs.br/handle/10183/223088

Soliman AM, Cohen SL, Bucak E, et al. Effectiveness of laparoscopic surgery for endometriosis. J Obstet Gynaecol [Internet]. 2020 May [cited 2025 Oct 9];40(5):510-516. Available from: https://doi.org/10.1080/01443615.2019.1678034

Ziegler D, Helmerhorst TJM, Farquhar CM, et al. Hysterectomy for endometriosis: Outcomes and indications. Fertil Steril [Internet]. 2020 Mar [cited 2025 Oct 9];113(3):579-587. Available from: https://www.researchgate.net/publication/346071454_Hysterectomy_for_Endometriosis_Surgical_Outcomes_Based_on_Surgeon_Specialty

Liu X, Zhu L, Zhang Y, et al. Antagonists of GnRH: A breakthrough in the hormonal therapy of endometriosis. Reprod Biol Endocrinol [Internet]. 2020 [cited 2025 Oct 9];18(1):34-41. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC12239828/

Liu H, Wang Q, Li J, et al. GnRH antagonists for endometriosis treatment: A systematic review. Hum Reprod Update [Internet]. 2020 Mar [cited 2025 Oct 9];26(2):133-145. Available from: https://pubmed.ncbi.nlm.nih.gov/36283862/

Forno SD, Nascimento BC, Ferreira T, et al. Transperineal ultrasound visual feedback assisted pelvic floor muscle physiotherapy in women with deep infiltrating endometriosis and dyspareunia: a pilot study. J Sex Marital Ther [Internet]. 2020 [cited 2025 Oct 6];46(7):603–11. Available from: https://pubmed.ncbi.nlm.nih.gov/32579077/

Podgaec S, Caraça D, Lobel A, Bellelis P, Portugal Lasmar B, Pires Costa C, et al. Endometriose. Femina [Internet]. 2020 [cited 2025 Oct 6];48(4):233–40. Available from: https://docs.bvsalud.org/biblioref/2020/05/1096077/femina-2019-484-233-237.pdf

Mira TAA, Yela DA, Podgaec S, Baracat EC, Benetti-Pinto CL. Hormonal treatment isolated versus hormonal treatment associated with electrotherapy for pelvic pain control in deep endometriosis: randomized clinical trial. Eur J Obstet Gynecol Reprod Biol [Internet]. 2020 Dec [cited 2025 Oct 6];255:134–41. Available from: https://pubmed.ncbi.nlm.nih.gov/33129015/

Ronchi DCM, Silva FS, Souza LC, et al. Desafios no desenvolvimento de prontuários eletrônicos baseados em arquétipos: avaliação fisioterapêutica funcional. Fisioterapia em Movimento [Internet]. 2012 Jul [cited 2025 Oct 9];25(3):497-506. Available from: https://www.scielo.br/j/fm/a/L3zxr4bnyS4ZpfchBQrFdvg/?lang=pt

Sousa B, Queiroz R, Paula A, Baron F, Flores R, et al. ConScientiae Saúde [Internet]. [cited 2025 Oct 9]. Available from: https://periodicos.uninove.br/saude/article/view/5511

Published

2025-10-20

How to Cite

Advances in endometriosis management, diagnosis, treatment, and impacts on fertility: A literature review. (2025). Fisioterapia Brasil, 26(5), 2676-2688. https://doi.org/10.62827/fb.v26i5.1103

Most read articles by the same author(s)