Hemodynamic effect of handgrip during cyclic exercise a randomized crossover clinical trial: Study protocol
DOI:
https://doi.org/10.62827/fb.v26i5.1099Keywords:
Hemodynamics; Vascular Resistance; Arterial Pressure.Abstract
Introduction: The combination of dynamic and isometric exercises, such as cyclic exercise with Handgrip contraction, may influence hemodynamic responses, improving cardiovascular regulation and offering new insights into exercise-based interventions. Objective: To test the hypothesis that isometric contraction with the Handgrip device modulates the response of heart rate, systolic and diastolic blood pressure, double product, and subjective perception of exertion (Borg) during cyclic exercise. Methods: This randomized crossover clinical trial consists of three intervention arms. Forty male volunteers aged between 20 and 30 will be recruited. After screening, the volunteers will be randomized to treatment protocols (I: without HG; II: with HG at 30% of Handgrip Strength - HGS and III: with HG at 50% of HGS) which involve performing cyclic exercise on a treadmill, with four sprints at moderate intensity. The data will be presented by the variation (∆) of the sprint-rest and post-exercise-rest moments. The one-way Analysis of Variance (ANOVA) test will be performed in the case of symmetrical distribution and Kruskal-Wallys for non-parametric distribution, to analyze the three protocols during the same phases and then the same test to evaluate the individual responses over time. A p≤0.05 will be considered statistically significant. Impact of the project: This study will provide answers to the hemodynamic effects of isometric activity with handgrip associated with cyclic exercise and, if the hypotheses of this study are confirmed, we will have robust mechanistic evidence to broaden the field of scientific exploration in different clinical contexts.
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Copyright (c) 2025 Marvyn de Santana do Sacramento, Josias Melo Leite, Maria Williane de Sousa Ribeiro, Uilma Sacramento Santana, Hellen Carvalho Salviano, Alice Miranda de Oliveira, Ramon Martins Barbosa, Pedro Elias Santos Souza, Jefferson Petto (Autor)
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